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Welcome to New Insights into HE, an educational website developed for physicians and other healthcare providers with an interest in improving the identification and management of patients with hepatic encephalopathy (HE).

This website has eight core educational ‘Modules’ which were developed by the New Insights Steering Committee faculty. These modules review the pathogenesis of HE, the burden on patients and healthcare resources and appropriate diagnosis and management. There are also interactive, case-based activities, to help you consider how you will apply the information presented, and a summary of the must know literature in the field.

Please also access the ‘Updates’ tab for updates and highlights of the latest data which will ensure you remain informed and up to date about HE.

Instructions for use of this website

  • The on-demand core educational modules can be accessed in any order
  • Please review faculty disclosures in the ‘disclosures’ tab
  • The complete list of modules is available on the ‘Modules’ tab. This will indicate which modules you have successfully completed. On accessing the module please review the short pre-activity information
  • After completion of each module, and sucessfullly passing a short post-activity test and your evaluation you will be able to access your certificate of completion
  • Updates and guest activities, as well as links to useful resources and a ‘presentation to go’ are available in the ‘Updates’ tab

Disclaimer: Use of medicinal products
according to approved indications

The educational content has been developed by an expert faculty and reflects up-to-date data and their clinical expertise. Some of the pharmaceutical products mentioned have approved indications which vary between countries and some therapies mentioned are not approved for the treatment of hepatic encephalopathy, or are not available in all countries.

When reviewing the content within this educational website, it is the responsibility of the learner to check the approved indications and recommended doses of any therapies mentioned.

The Summary of Product Characteristics (SPCs) for EMA CHMP-approved products can be found on the EMA website (, or from the relevant manufacturer. For users of this website based in the United Kingdom, current SPCs for most therapies can be found at

An application has been made to the EACCME© for CME accreditation of this website.

The New Insights into HE Steering Committee

This programme has been developed under the direction of the
New Insights into HE Steering Committee:
Professor Rajiv Jalan (Course Director)
Royal Free Hospital/UCL Medical School, London, UK
Professor Juan Cordoba (Deceased)
Hospital Vall d’Hebron/Autonomous University of Barcelona, Barcelona, Spain
Dr. Gerald Kircheis
UKD (University Hospital Düsseldorf), Düsseldorf, Germany
Dr. Robert J. de Knegt
Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands
Professor Wim Laleman
University Hospital Gasthuisberg, Leuven, Belgium
Professor Fin Stolze Larsen
Rigshospitalet, University Hospital, Denmark
Dr. Peter Ott
Aarhus University Hospital, Aarhus, Denmark
Dr. Debbie Shawcross
King's College Hospital/King's College, London School of Medicine, London, UK
Professor Heiner Wedemeyer
Hannover Medical School, Hannover, Germany

Editorial Assistance
Content development was supported by Ian Morgan MSc, Helen Jones PhD and Alison Howe, 4C Consultants International.

Responsible Medical Practitioner

As Course Director, Professor Rajiv Jalan has taken responsibility for the content of this website.

Professor Rajiv Jalan
Professor Hepatology
Liver Failure Group, Royal Free Hospital/UCL Medical School,
Rowland Hill St, London, NW3 2PF, UK
Tel:+44 (0)207 433 2795

Registration number: 3635935
Regulatory Authority: General Medical Council, UK

GL/XIF/1014/0064a(1). Date of preparation: June 2015.

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